Clinical and Molecular Epidemiology of Acinetobacter Baumannii Bloodstream Infections in an Endemic Setting

Future Microbiol. 2017 Mar;12:271-283. doi: 10.2217/fmb-2016-0158. Epub 2017 Feb 24.

Abstract

Aim: The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata.

Methods & results: Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A. baumannii acquisitions in health facilities. Moreover, all patients who died immediately (<24 h of admission) were infected with a single clone (ST457; relative risk = 1.6; p = 0.05).

Conclusion: This preliminary analysis should prompt further investigation by mapping genomic virulence determinants among A. baumannii ST457 lineage compared with other strains.

Keywords: Gram-negative; MDR; MLST; carbapenem; nonfermenter; nosocomial infections; typing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter Infections / mortality
  • Acinetobacter Infections / transmission
  • Acinetobacter baumannii / classification
  • Acinetobacter baumannii / genetics*
  • Acinetobacter baumannii / isolation & purification
  • Acinetobacter baumannii / physiology
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteremia / microbiology*
  • Bacteremia / mortality
  • Bacteremia / transmission
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Child
  • Child, Preschool
  • Cross Infection / epidemiology
  • Cross Infection / microbiology
  • Female
  • Humans
  • Infant
  • Israel / epidemiology
  • Male
  • Middle Aged
  • Molecular Epidemiology
  • Phylogeny
  • Retrospective Studies
  • Young Adult

Substances

  • Bacterial Proteins