Perivascular medical devices and drug delivery systems: Making the right choices

Biomaterials. 2017 Jun:128:56-68. doi: 10.1016/j.biomaterials.2017.02.028. Epub 2017 Feb 28.


Perivascular medical devices and perivascular drug delivery systems are conceived for local application around a blood vessel during open vascular surgery. These systems provide mechanical support and/or pharmacological activity for the prevention of intimal hyperplasia following vessel injury. Despite abundant reports in the literature and numerous clinical trials, no efficient perivascular treatment is available. In this review, the existing perivascular medical devices and perivascular drug delivery systems, such as polymeric gels, meshes, sheaths, wraps, matrices, and metal meshes, are jointly evaluated. The key criteria for the design of an ideal perivascular system are identified. Perivascular treatments should have mechanical specifications that ensure system localization, prolonged retention and adequate vascular constriction. From the data gathered, it appears that a drug is necessary to increase the efficacy of these systems. As such, the release kinetics of pharmacological agents should match the development of the pathology. A successful perivascular system must combine these optimized pharmacological and mechanical properties to be efficient.

Keywords: Cuff; Intimal hyperplasia; Mesh; Periadventitial administration; Perivascular administration; Wrap.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Vessels / physiology*
  • Blood Vessels / physiopathology
  • Clinical Trials as Topic
  • Drug Delivery Systems*
  • Drug Liberation
  • Equipment and Supplies*
  • Humans
  • Tissue Distribution