Aggregatibacter actinomycetemcomitans osteomyelitis in a 12 year old boy: case report emphasizing the importance of tissue culture, and review of literature

Ann Clin Microbiol Antimicrob. 2017 Mar 14;16(1):12. doi: 10.1186/s12941-017-0186-0.

Abstract

Background: Aggregatibacter actinomycetemcomitans most commonly causes periodontitis but has been reported to infect heart valves, soft tissue, brain and lungs, and distal bones. Osteomyelitis distal to the jaw is rarely described.

Case presentation: We report an unusual and rare case of chronic osteomyelitis caused by A. actinomycetemcomitans in the toe of a paediatric patient, and review the available literature. The infection was managed with intravenous antibiotics followed by oral antibiotics.

Conclusion: This is an unusual presentation of A. actinomycetemcomitans causing chronic osteomyelitis presumed due to nidation in a minimally damaged bone, associated with bacteraemia of an oral commensal. It occurred in the toe, without obvious dental predisposition; associated with minimal clinical disturbance and with muted immune response.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aggregatibacter actinomycetemcomitans / isolation & purification
  • Aggregatibacter actinomycetemcomitans / pathogenicity*
  • Amoxicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteremia / drug therapy*
  • Cefotaxime / therapeutic use
  • Child
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / microbiology*
  • Toes / microbiology*
  • Toes / pathology

Substances

  • Anti-Bacterial Agents
  • Amoxicillin
  • Cefotaxime