Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype

Mineji Hayakawa

doi:10.1186/s40560-016-0200-1

Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype

J Intensive Care. 2017 Jan 31:5:14. doi: 10.1186/s40560-016-0200-1. eCollection 2017.

Author

Mineji Hayakawa¹

Affiliation

¹ Emergency and Critical Care Center, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, 060-8648 Japan.

Abstract

In severe trauma patients, coagulopathy is frequently observed in the acute phase of trauma. Trauma-induced coagulopathy is coagulopathy caused by the trauma itself. The pathophysiology of trauma-induced coagulopathy consists of coagulation activation, hyperfibrino(geno)lysis, and consumption coagulopathy. These pathophysiological mechanisms are the characteristics to DIC with the fibrinolytic phenotype.

Keywords: Coagulopathy; Disseminated intravascular coagulation; Fibrinogen; Fibrinolysis; Massive bleeding; Transfusion; Trauma.

Publication types

Review