Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme

Chem Commun (Camb). 2017 Mar 23;53(25):3579-3582. doi: 10.1039/c6cc08873b.

Abstract

Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced α-hydroxy-β-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h-1).

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Chlorohydrins / chemistry*
  • Coordination Complexes / chemistry
  • Molecular Conformation
  • Ruthenium / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Stereoisomerism

Substances

  • Alkenes
  • Chlorohydrins
  • Coordination Complexes
  • Ruthenium