Autoradiographic localization of opioid receptor types in the rat small intestine

NIDA Res Monogr. 1986;75:315-8.

Abstract

The selective mu and delta ligands [3H]DAGO and [3H]DPDPE have been used to investigate the distribution of specific opioid subtypes in the rat small intestine by in vitro autoradiography. There was a greater density of [3H]DPDPE binding at regions of the villi and crypts than [3H]DAGO binding. These results suggest that the opioid receptors located in these regions are predominantly of the delta subtype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
  • Enkephalin, D-Penicillamine (2,5)-
  • Enkephalins / metabolism
  • Intestine, Small / cytology
  • Intestine, Small / metabolism*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Opioid / metabolism*
  • Receptors, Opioid, delta
  • Receptors, Opioid, mu
  • Tritium

Substances

  • Enkephalins
  • Receptors, Opioid
  • Receptors, Opioid, delta
  • Receptors, Opioid, mu
  • Tritium
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
  • Enkephalin, D-Penicillamine (2,5)-