Sequential nailfold videocapillaroscopy examinations have responsiveness to detect organ progression in systemic sclerosis

Semin Arthritis Rheum. 2017 Aug;47(1):86-94. doi: 10.1016/j.semarthrit.2017.02.006. Epub 2017 Feb 10.


Objective: To determine the merit of nailfold videocapillaroscopy (NVC) to detect meaningful microvascular changes over time in patients with systemic sclerosis (SSc) and whether these changes are associated with overall disease progression and organ involvements.

Methods: A prospective cohort of 140 SSc patients was recruited over a 12-month period and was followed up on an annual basis for 3 years. Detailed NVC analysis was performed at inclusion and repeated annually. Disease progression and organ damage were defined according to validated definitions.

Results: Significant NVC changes were detected in 72 SSc patients (51%) during the follow-up period. Patients with incident or increased number of giant capillaries were less at risk to develop new digital ulcers (DU) [hazard ratio (HR) = 0.53, 95% confidence interval (CI): 0.07-0.93]. Loss of capillaries over time was confirmed as a robust and independent marker of organ progression. The reduction of the number of capillaries was associated with overall disease progression (HR = 4.35, 95% CI: 1.87-10.12), occurrence of new DU (HR = 5.33, 95% CI: 1.69-16.71), lung vascular progression (HR = 18.53, 95% CI: 1.28-78.33), progression of skin fibrosis (HR = 4.22, 95% CI: 1.24-14.36), and worsening of the Medsger severity score (HR = 5.26, 95% CI: 1.78-15.52).

Conclusion: Significant NVC changes are observed in almost half of the patients with SSc during a follow-up of 3 years. Sequential NVC examinations have responsiveness to detect disease progression. Sequential NVC is confirmed of value to monitor SSc, as well as progressive loss of capillaries over time as a potential surrogate marker for disease progression.

Keywords: Digital ulcers; Disease progression; Nailfold videocapillaroscopy; Systemic sclerosis.

MeSH terms

  • Aged
  • Disease Progression*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Microscopic Angioscopy / methods*
  • Microscopy, Video
  • Middle Aged
  • Nails / blood supply
  • Nails / diagnostic imaging*
  • Predictive Value of Tests
  • Proportional Hazards Models
  • Prospective Studies
  • Scleroderma, Systemic / complications*
  • Scleroderma, Systemic / physiopathology
  • Severity of Illness Index*