RNA Methylation Clears the Way

Dev Cell. 2017 Mar 13;40(5):427-428. doi: 10.1016/j.devcel.2017.02.024.


During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.

Publication types

  • Comment

MeSH terms

  • Gene Expression Regulation, Developmental
  • Methylation
  • RNA Stability
  • RNA, Messenger / genetics
  • RNA, Messenger, Stored / genetics*
  • Zygote*


  • RNA, Messenger
  • RNA, Messenger, Stored