Reactive Arthritis

Infect Dis Clin North Am. 2017 Jun;31(2):265-277. doi: 10.1016/j.idc.2017.01.002. Epub 2017 Mar 11.


Reactive arthritis is classified as a spondyloarthropathy. Current concepts of disease suggest an infectious trigger, followed by inflammatory arthritis. Several mechanisms have been proposed to explain the interaction of host susceptibility and microorganism. Diagnosis relies on a compatible clinical syndrome and microbiologic confirmation of the pathogen. Antibiotic therapy seems useful in Chlamydia-triggered arthritis. The role of antibiotics in arthritis triggered by enteric pathogens is less clear. The role of tumor necrosis factor alpha inhibitors in therapy is evolving. Many patients have a course limited to a few months, but others experience extraarticular disease and more prolonged courses.

Keywords: Campylobacter; Chlamydia; Inflammatory arthritis; Reactive arthritis; Salmonella; Shigella; Spondyloarthropathy; Yersinia.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Arthritis, Reactive / complications
  • Arthritis, Reactive / drug therapy*
  • Arthritis, Reactive / microbiology*
  • Arthritis, Reactive / physiopathology
  • Campylobacter Infections / complications
  • Campylobacter Infections / drug therapy
  • Chlamydia Infections / complications
  • Chlamydia Infections / drug therapy
  • Dysentery, Bacillary / complications
  • Dysentery, Bacillary / drug therapy
  • Female
  • Humans
  • Male
  • Salmonella Infections / complications
  • Salmonella Infections / drug therapy
  • Yersinia Infections / complications
  • Yersinia Infections / drug therapy


  • Anti-Bacterial Agents