Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials

Diabetes Res Clin Pract. 2017 May:127:1-9. doi: 10.1016/j.diabres.2017.01.021. Epub 2017 Mar 2.


Objective: Postprandial hyperglycemia plays a decisive role in the development of chronic metabolic disorders. The effect of vinegar intake with a meal on postprandial glucose has been studied in several trials with conflicting results.

Research methods and procedures: The purpose of the current study was to systematically review control trials that report on the effect of vinegar intake on postprandial glucose response. Postprandial insulin response was considered as secondary outcome.

Results: The pooled analysis of studies revealed a significant mean glucose and insulin area under the curve (AUC) reduction in participants who consumed vinegar compared with the control group (standard mean difference=-0.60, 95%CI -1.08 to -0.11, p=0.01 and -1.30, 95%CI -1.98 to -0.62, p<0.001, respectively).

Conclusions: The findings suggest that vinegar can be effective in reducing postprandial glucose and insulin levels, indicating it could be considered as an adjunctive tool for improving glycemic control.

Keywords: Acetic acid; Glucose; Insulin; Postprandial; Vinegar.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Acetic Acid / therapeutic use*
  • Blood Glucose / metabolism*
  • Cross-Over Studies
  • Female
  • Humans
  • Hyperglycemia / drug therapy
  • Insulin / metabolism*
  • Male
  • Postprandial Period / physiology*


  • Blood Glucose
  • Insulin
  • Acetic Acid