Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16

Jia-Hui Xu; Kang-Bo Gu; Dao-Jing Zhang; Yuan-Guang Li; Li Tian

doi:10.1038/ja.2017.37

Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16

J Antibiot (Tokyo). 2017 Jun;70(6):733-736. doi: 10.1038/ja.2017.37. Epub 2017 Mar 15.

Authors

Jia-Hui Xu¹, Kang-Bo Gu¹, Dao-Jing Zhang¹, Yuan-Guang Li¹, Li Tian²

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
² First Institute of Oceanography, State Oceanic Administration, Qingdao, China.

PMID: 28293035
DOI: 10.1038/ja.2017.37

Abstract

Two novel γ-butyrolactones ghanamycins A (1) and B (2) were isolated from the fermentation broth of marine-derived Streptomyces ghanaensis TXC6-16. Their structures were elucidated by spectroscopic analysis. These two novel compounds exhibited antimicrobial activities against some phytopathogens. The minimum IC (MIC) of 2 against Pseudomonas syringae and Erwinia sp. were 50 μg ml^-1.

MeSH terms

4-Butyrolactone / analogs & derivatives*
4-Butyrolactone / chemistry
4-Butyrolactone / isolation & purification*
4-Butyrolactone / pharmacology
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology
Erwinia / drug effects
Fermentation
Microbial Sensitivity Tests
Pseudomonas syringae / drug effects
Spectrum Analysis
Streptomyces / metabolism*

Substances

Anti-Infective Agents
ghanamycin A
ghanamycin B
4-Butyrolactone