Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
, 42 (1), 94-97

Kikuchi-Fujimoto Disease: A Rare Presentation With Localized Iliac Lymphadenitis

Affiliations
Case Reports

Kikuchi-Fujimoto Disease: A Rare Presentation With Localized Iliac Lymphadenitis

Shrihari Anil Anikhindi et al. Iran J Med Sci.

Abstract

Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disease characterized by histiocytic necrotising lymphadenitis. Though several viral agents or an autoimmune etiology has been proposed as causative, the exact cause remains unknown. It has a female predilection and most commonly seen among young Asian people. Patients usually present with a febrile illness and the presence of lymphadenopathy may provide a clue to diagnosis. The most common site of lymphadenopathy is cervical lymph nodes while intra-abdominal involvement is uncommon. Cases of KFD presenting with intra-abdominal lymphadenopathy have been reported to occur with equal frequency in both sexes. Abdominal tuberculosis, non-Hodgkin's lymphoma, and systemic lupus erythematosus are close differential diagnoses for this type of presentation. Treatment is mostly supportive as the disease usually resolves spontaneously; steroids are only required in severe cases. We report a 32-year-old male patient of intra-abdominal lymphadenitis that presented as fever of unknown origin (FUO) and diagnosed by excisional biopsy as a case of KFD.

Keywords: Abdomen; Fever of unknown origin; Histiocytic necrotising lymphadenitis.

Figures

Figure 1
Figure 1
Lymph node showing geographic areas of necrosis with focally preserved follicles (H&E, 40×).
Figure 2
Figure 2
Lymph node showing large areas of necrosis with focally preserved follicles (H&E, 100×).
Figure 3
Figure 3
Necrosis with prominent karryorrhectic debris, which is devoid of neutrophils and plasma cells (H&E, 400×).

Similar articles

See all similar articles

References

    1. Rosado FG, Tang YW, Hasserjian RP, McClain CM, Wang B, Mosse CA. Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8. Hum Pathol. 2013;44:255–9. doi: 10.1016/j.humpath.2012.05.016. - DOI - PubMed
    1. Patra A, Bhattacharya SK. SLE Developing in a Follow-Up Patient of Kikuchi’s Disease: A Rare Disorder. J Clin Diagn Res. 2013;7:752–3. doi: 10.7860/JCDR/2013/5017.2904. [ PMC Free Article] - DOI - PMC - PubMed
    1. Duskin-Bitan H, Kivity S, Olchovsky D, Schiby G, Ezra D, Mouallem M. Kikuchi-Fujimoto disease. Isr Med Assoc J. 2010;12:617–21. - PubMed
    1. Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2004;122:141–52. doi: 10.1309/YF08-1L4T-KYWV-YVPQ. - DOI - PubMed
    1. Sousa Ade A, Soares JM, Sa Santos MH, Martins MP, Salles JM. Kikuchi-Fujimoto disease: three case reports. Sao Paulo Med J. 2010;128:232–5. - PubMed

Publication types

LinkOut - more resources

Feedback