Efficacy of neutrophil non-muscle myosin heavy chain-IIA immunofluorescence analysis in determining the pathogenicity of MYH9 variants

Ann Hematol. 2017 Jun;96(6):1065-1066. doi: 10.1007/s00277-017-2972-3. Epub 2017 Mar 14.

Authors

Shinji Kunishima¹, Okuno Yusuke², Hideki Muramatsu³, Daiei Kojima³, Noriko Nagai⁴, Yoshiyuki Takahashi³, Seiji Kojima³

Affiliations

¹ Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, 4600001, Japan. kunishis@nnh.hosp.go.jp.
² Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
³ Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁴ Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan.

PMID: 28293712
DOI: 10.1007/s00277-017-2972-3

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Blood Platelets / chemistry
Blood Platelets / ultrastructure
Causality
Child
Computer Simulation
DNA Mutational Analysis / methods
Female
Fluorescent Antibody Technique, Direct*
Humans
Inclusion Bodies / chemistry
Inclusion Bodies / ultrastructure
Male
Molecular Motor Proteins / analysis
Molecular Motor Proteins / chemistry
Molecular Motor Proteins / genetics*
Mutation, Missense*
Myosin Heavy Chains / analysis
Myosin Heavy Chains / chemistry
Myosin Heavy Chains / genetics*
Neutrophils / chemistry
Neutrophils / ultrastructure*
Staining and Labeling
Thrombocytopenia / complications
Thrombocytopenia / congenital
Thrombocytopenia / genetics*

Substances

MYH9 protein, human
Molecular Motor Proteins
Myosin Heavy Chains