The substitution V379I in PA protein attenuates the pathogenicity of influenza A (H1N1) pdm09 viruses in mice

Sci China Life Sci. 2017 Sep;60(9):1044-1046. doi: 10.1007/s11427-016-9018-8. Epub 2017 Mar 13.
No abstract available

Publication types

  • Letter

MeSH terms

  • Amino Acid Substitution*
  • Animals
  • Cattle
  • Dogs
  • Female
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Humans
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / pathogenicity*
  • Madin Darby Canine Kidney Cells
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections / virology*
  • RNA-Dependent RNA Polymerase / genetics*
  • Viral Proteins / genetics*
  • Virulence / genetics
  • Virus Replication / genetics

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • PA protein, influenza viruses
  • Viral Proteins
  • RNA-Dependent RNA Polymerase