Alcohol Induced Hepato Cardiotoxicity and Oxidative Damage in Rats: The Protective Effect of n-butanol Extract of Green Tea (Camellia sinensis (L.) Kuntze)

Cardiovasc Hematol Disord Drug Targets. 2017 Jul 4;17(1):18-23. doi: 10.2174/1871529X17666170310101727.


Background: The principal aim of this study was to investigate the oxidative effects of acute alcohol consumption on the functions of the heart and the liver and the possible modification of this effect by phenolic compounds from n-butanol extract of Camellia sinensis supplementation.

Method: Three experimental groups of rats were used: control, ethanol-exposed (40% v/v, 5 g/kg per oral every 12 hours for 3 doses, binge model), and ethanol-exposed plus n-butanol extract of Camellia sinensis (100 mg/kg once a day for three days before and simultaneously with ethanol administration). Serum transaminases, cholesterol, triglycerides, lipid peroxidation (MDA), reduced glutathione (GSH) and glutathione peroxidase (GPx) were estimated to assess organs damage.

Results: n-butanol extract of Camellia sinensis at a dose of 100 mg/kg body weight exhibited a significant reversal effect in all biochemical parameters measured such as extent of lipid peroxidation, GSH, lipid profile, and serum aminotransferase activities.

Conclusion: These results suggest that n-butanol extract of Camellia sinensis protected the heart and the liver from binge ethanol induced injury through attenuating oxidative stress.

Keywords: Alcohol; Camellia sinensis; antioxidant; cardiotoxicity; hepatotoxicity; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Butanol / chemistry
  • Alcohol Drinking / adverse effects
  • Alcohol Drinking / blood
  • Alcohol Drinking / metabolism
  • Animals
  • Antioxidants / chemistry
  • Antioxidants / therapeutic use*
  • Camellia sinensis / chemistry*
  • Cardiotoxicity / blood
  • Cardiotoxicity / drug therapy*
  • Cardiotoxicity / etiology
  • Cardiotoxicity / metabolism
  • Ethanol / toxicity*
  • Female
  • Lipid Peroxidation / drug effects
  • Liver Diseases, Alcoholic / blood
  • Liver Diseases, Alcoholic / drug therapy*
  • Liver Diseases, Alcoholic / etiology
  • Liver Diseases, Alcoholic / metabolism
  • Oxidative Stress / drug effects*
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*
  • Rats
  • Tea / chemistry


  • Antioxidants
  • Plant Extracts
  • Tea
  • Ethanol
  • 1-Butanol