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. 2017 Apr 28;80(4):1015-1019.
doi: 10.1021/acs.jnatprod.6b01016. Epub 2017 Mar 15.

Antimicrobial Metabolites from Streptomyces sp. SN0280

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Antimicrobial Metabolites from Streptomyces sp. SN0280

Hui Tian et al. J Nat Prod. .

Abstract

One new indole derivative, chloroindole (1), one new diketone, streptoone A (2), two new ketonic acids, streptoones B (3) and C (4), and one known macrolide antibiotic, X-14952B (5), were isolated from Streptomyces sp. SN0280. Extensive NMR, HRESIMS, and IR analysis was used to elucidate their structures. Streptoone A (2) displayed antibacterial activity (MIC value of 7.81 μg/mL) against Clavibater michiganensis, comparable with the positive control streptomycin (MIC value of 7.81 μg/mL). Streptoone B (3) showed antifungal activity (MIC value of 15.63 μg/mL) against Phytophthora capsici (positive control carbendazol MIC value of 7.81 μg/mL). These molecules provide new templates for the potential treatment and management of these phytopathogens.

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