Sperm DNA fragmentation as a result of ultra-endurance exercise training in male athletes

Andrologia. 2018 Feb;50(1). doi: 10.1111/and.12793. Epub 2017 Mar 15.

Abstract

Intensive sports practice seems to exert negative effects on semen parameters; in order to assess these effects, the objective of this study was to assess semen, including DNA fragmentation, and hormone parameters in elite triathletes. Twelve high-level triathletes preparing for a National Triathlon Championship participated in the study. The qualitative sperm parameters analysed were volume, sperm count, motility, morphology and DNA fragmentation; when needed, additional testing was performed. Assessed hormones were testosterone (T), cortisol (C) and testosterone-cortisol ratio (T/C). Maximum oxygen consumption and training characteristics were also assessed. Hormonal values and physical semen parameters were within normal ranges. DNA fragmentation showed high values (20.4 ± 6.1%). Round cells in semen were higher than normal (2.8 ± 1.5 million/ml), with the presence of macrophages. Correlations were found for several parameters: concentration of round cells positively correlated with progressive sperm motility (p = .01) and sperm morphology (p = .02); contrarily, the correlation found with DNA fragmentation was negative (p = .04). Sperm DNA fragmentation and the T/C ratio, however, were correlated in a positive manner (p = .03). As evidenced by the observed results, sperm DNA fragmentation is affected by high-level sports practice; therefore, high loads of endurance training could potentially interfere with the athlete's fertility potential.

Keywords: endurance training; hormones; macrophages; semen; triathlon.

MeSH terms

  • Adult
  • Athletes*
  • DNA Fragmentation*
  • Humans
  • Male
  • Physical Conditioning, Human / physiology*
  • Physical Endurance / genetics*
  • Semen Analysis
  • Sperm Count
  • Sperm Motility / physiology
  • Spermatozoa / metabolism*
  • Young Adult