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Randomized Controlled Trial
. 2017 Mar;23(3):201-207.
doi: 10.1089/acm.2016.0140. Epub 2017 Feb 16.

Treatment of Major Depressive Disorder With Iyengar Yoga and Coherent Breathing: A Randomized Controlled Dosing Study

Free PMC article
Randomized Controlled Trial

Treatment of Major Depressive Disorder With Iyengar Yoga and Coherent Breathing: A Randomized Controlled Dosing Study

Chris C Streeter et al. J Altern Complement Med. .
Free PMC article


Objectives: The aims of this study were to assess the effects of an intervention of Iyengar yoga and coherent breathing at five breaths per minute on depressive symptoms and to determine optimal intervention yoga dosing for future studies in individuals with major depressive disorder (MDD).

Methods: Subjects were randomized to the high-dose group (HDG) or low-dose group (LDG) for a 12-week intervention of three or two intervention classes per week, respectively. Eligible subjects were 18-64 years old with MDD, had baseline Beck Depression Inventory-II (BDI-II) scores ≥14, and were either on no antidepressant medications or on a stable dose of antidepressants for ≥3 months. The intervention included 90-min classes plus homework. Outcome measures were BDI-II scores and intervention compliance.

Results: Fifteen HDG (Mage = 38.4 ± 15.1 years) and 15 LDG (Mage = 34.7 ± 10.4 years) subjects completed the intervention. BDI-II scores at screening and compliance did not differ between groups (p = 0.26). BDI-II scores declined significantly from screening (24.6 ± 1.7) to week 12 (6.0 ± 3.8) for the HDG (-18.6 ± 6.6; p < 0.001), and from screening (27.7 ± 2.1) to week 12 (10.1 ± 7.9) in the LDG (-17.7 ± 9.3; p < 0.001). There were no significant differences between groups, based on response (i.e., >50% decrease in BDI-II scores; p = 0.65) for the HDG (13/15 subjects) and LDG (11/15 subjects) or remission (i.e., number of subjects with BDI-II scores <14; p = 1.00) for the HDG (14/15 subjects) and LDG (13/15 subjects) after the 12-week intervention, although a greater number of subjects in the HDG had 12-week BDI-II scores ≤10 (p = 0.04).

Conclusion: During this 12-week intervention of yoga plus coherent breathing, depressive symptoms declined significantly in patients with MDD in both the HDG and LDG. Both groups showed comparable compliance and clinical improvements, with more subjects in the HDG exhibiting BDI-II scores ≤10 at week 12.

Keywords: Iyengar; breathing; depression; dosing; randomized; yoga.

Conflict of interest statement

Dr. Brown and Dr. Gerbarg teach and have published Breath∼Body∼Mind©, a technique that uses coherent breathing. Dr. Streeter is certified to teach Breath∼Body∼Mind©. No competing financial interests exist for the remaining authors.


<b>FIG. 1.</b>
FIG. 1.
Flowchart of subject recruitment through completion.
<b>FIG. 2.</b>
FIG. 2.
Beck Depression Inventory-II (BDI-II) versus Cumulative Yoga Minutes for high-dose group (HDG) and low-dose group (LDG) (mean ± SEM).

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    1. Smith K. Mental health: A world of depression. Nature 2014;515:181. - PubMed
    1. Thase M, Nierenberg AA, Vrijland P, et al. Remission with mirtazapine and selective serotonin reuptake inhibitors: A meta-analysis of individual patient data from 15 controlled trials of acute phase treatment of major depression. Int Clin Psychopharmacol 2010;25:189–198 - PubMed
    1. Insel T, Wang P. The STAR*D trial: Revealing the need for better treatments. Psychiatr Serv 2009;60:1466–1467 - PubMed
    1. Uebelacker L, Broughton M. Yoga for depression and anxiety: A review of published research and implications for healthcare providers. R I Med J 2016;99:20–22 - PubMed
    1. Cramer H, Lauche R, Langhorst J, et al. Yoga for depression: A systematic review and meta-analysis. Depress Anxiety 2013;30:1068–1083 - PubMed

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