Immunohistochemical Staining of Pediatric Solitary Angiokeratomas

Pediatr Dermatol. 2017 Mar;34(2):211-213. doi: 10.1111/pde.13089.


The precise etiology and subtype of vessels constituting angiokeratomas is poorly understood. We sought to characterize the vessels by studying prospero-related homeobox gene-1 and D2-40 expression in 22 pediatric solitary angiokeratomas. Routine histologic examination demonstrated a mix of lymph-containing vessels and erythrocyte-filled small vessels. Our results suggest that angiokeratomas may in part be comprised of vessels with lymphatic differentiation.

MeSH terms

  • Adolescent
  • Angiokeratoma / pathology*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Retrospective Studies
  • Skin Neoplasms / pathology*