Organisation of the regulatory region of the Escherichia coli melibiose operon

Gene. 1987;59(2-3):253-63. doi: 10.1016/0378-1119(87)90333-7.


The regulatory region of the Escherichia coli melibiose operon contains two divergent promoters. One promoter is responsible for the expression of the melR gene, that is essential for melibiose-dependent stimulation of the second promoter. Melibiose-induced transcription from this second promoter initiates at a start point 25 bp upstream from the start codon of the melA gene, encoding an alpha-galactosidase. The nucleotide sequence covering the divergent promoters and the melR gene is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Restriction Enzymes
  • Disaccharides / genetics*
  • Escherichia coli / genetics*
  • Genes*
  • Genes, Bacterial*
  • Genes, Regulator*
  • Melibiose / genetics*
  • Molecular Sequence Data
  • Operon*
  • Plasmids
  • Promoter Regions, Genetic
  • Transcription, Genetic
  • beta-Galactosidase / genetics


  • Disaccharides
  • Melibiose
  • DNA Restriction Enzymes
  • beta-Galactosidase

Associated data

  • GENBANK/M18425