Systems Biology of Metabolism

Annu Rev Biochem. 2017 Jun 20:86:245-275. doi: 10.1146/annurev-biochem-061516-044757. Epub 2017 Mar 8.


Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.

Keywords: genome-scale metabolic models; metabolic engineering; metabolomics; proteomics; systems medicine; transcriptomics.

Publication types

  • Review

MeSH terms

  • Bacteria / genetics
  • Bacteria / metabolism
  • Fungi / genetics
  • Fungi / metabolism
  • Genome*
  • Humans
  • Kinetics
  • Metabolic Engineering
  • Metabolomics / methods
  • Metabolomics / statistics & numerical data*
  • Models, Biological*
  • Models, Statistical*
  • Proteomics
  • Systems Biology / methods
  • Systems Biology / statistics & numerical data*
  • Transcriptome*