Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: a Double-Blinded, Randomized Crossover Controlled Trial

Plant Foods Hum Nutr. 2017 Jun;72(2):126-133. doi: 10.1007/s11130-017-0605-6.


The aim of this study is to investigate the simultaneous effect of pomegranate juice on components of the metabolic syndrome, including high sensitive C-reactive protein (hs-CRP) as an inflammatory index and glycemic and lipid profile indices in patients with metabolic syndrome. In a double- blind 2*2 crossover study, 30 individuals suffering from metabolic syndrome received a daily dose of 500 mL pomegranate juice for a period of one week. After one week of wash out period, they received a placebo for one week. Lipid profile, blood glucose control indices including fasting blood glucose, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), systolic and diastolic blood pressure, and hs-CRP were measured at the beginning and end of the study. To analyze the data, a repeated measure analysis of variance and a t-test were performed. The results indicated that in comparison to the placebo, pomegranate juice was more effective in reducing the systolic and diastolic blood pressure (p = 0.00) and hs-CRP (p = 0.018). The level of triglyceride (p = 0.030) and very low-density lipoproteins cholesterol (VLDL-C) (p = 0.014) were increased after the consumption of pomegranate juice, as opposed to the baseline condition. The rest of lipid profile, fasting blood glucose (FBS), insulin, and HOMA-IR of the participants did not show any significant difference. Natural pomegranate juice supplementation lowered the level of systolic and diastolic blood pressure in patients with metabolic syndrome as well as their blood hs-CRP. However, it also increased their triglyceride and VLDL-C.

Keywords: Cardiovascular disease; Lipid profile; Metabolic syndrome; Pomegranate juice.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Pressure / drug effects
  • C-Reactive Protein / drug effects
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / prevention & control*
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Fruit and Vegetable Juices / analysis*
  • Humans
  • Inflammation / prevention & control
  • Lipoproteins, LDL / blood
  • Lipoproteins, LDL / drug effects
  • Lythraceae / chemistry*
  • Male
  • Metabolic Syndrome / prevention & control*
  • Middle Aged
  • Risk Factors
  • Triglycerides / blood
  • Young Adult


  • Lipoproteins, LDL
  • Triglycerides
  • C-Reactive Protein