Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.
Objective: We analyzed the correlation of plasma microparticle levels (MP) with AR.
Materials and methods: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation.
Results: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups.
Discussion and conclusion: MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation.
Keywords: T cell-derived microparticles; endothelial cell-derived microparticles; graft monitoring; non-invasive marker; regulatory T cells.