The value of microparticles in detecting acute rejection episodes after liver transplantation

Biomarkers. 2018 Feb;23(1):25-32. doi: 10.1080/1354750X.2017.1306754. Epub 2017 Apr 3.


Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.

Objective: We analyzed the correlation of plasma microparticle levels (MP) with AR.

Materials and methods: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation.

Results: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups.

Discussion and conclusion: MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation.

Keywords: T cell-derived microparticles; endothelial cell-derived microparticles; graft monitoring; non-invasive marker; regulatory T cells.

MeSH terms

  • CD4 Antigens / blood
  • CD8 Antigens / blood
  • Cell-Derived Microparticles / metabolism*
  • Female
  • Graft Rejection / blood*
  • Graft Rejection / diagnosis*
  • Graft Rejection / etiology
  • Humans
  • Liver Transplantation / adverse effects
  • Liver Transplantation / methods*
  • Male
  • Middle Aged
  • Platelet Endothelial Cell Adhesion Molecule-1 / blood
  • Time Factors


  • CD4 Antigens
  • CD8 Antigens
  • Platelet Endothelial Cell Adhesion Molecule-1