The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis

Allergy. 2017 Nov;72(11):1796-1800. doi: 10.1111/all.13160. Epub 2017 Apr 12.


Emerging evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiology. However, little is known about the combined role of airway microbiota and CCL5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1005 infants (age <1 year) hospitalized for bronchiolitis during 2011-2014, we observed statistically significant interactions between nasopharyngeal airway CCL5 levels and microbiota profiles with regard to the risk of both intensive care use (Pinteraction =.02) and hospital length-of-stay ≥3 days (Pinteraction =.03). Among infants with lower CCL5 levels, the Haemophilus-dominant microbiota profile was associated with a higher risk of intensive care use (OR, 3.20; 95%CI, 1.18-8.68; P=.02) and hospital length-of-stay ≥3 days (OR, 4.14; 95%CI, 2.08-8.24; P<.001) compared to the Moraxella-dominant profile. Conversely, among those with higher CCL5 levels, there were no significant associations between the microbiota profiles and these severity outcomes (all P≥.10).

Keywords: CCL5/RANTES; airway; bronchiolitis; microbiota; severity.

Publication types

  • Multicenter Study

MeSH terms

  • Bronchiolitis / etiology
  • Bronchiolitis / pathology*
  • Chemokine CCL5
  • Haemophilus
  • Humans
  • Infant
  • Infant, Newborn
  • Intensive Care Units
  • Length of Stay
  • Microbiota*
  • Moraxella
  • Nasopharynx / chemistry*
  • Nasopharynx / microbiology


  • CCL5 protein, human
  • Chemokine CCL5