Abstract
Cafamycin is a novel polyether antibiotic active against gram-positive bacteria. It was isolated from the culture fluid of Streptomyces sp., an organism producing the anthracycline antibiotic galtamycin. The structure of cafamycin was assessed by spectral analysis: UV, PMR, mass spectroscopy and CD. Physico-chemical and biological properties of the antibiotic are described. Cafamycin was shown to be an analog of indanomycin (X-14547A), a pyrrol ether antibiotic.
MeSH terms
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Anti-Bacterial Agents / analysis
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antibiotics, Antineoplastic
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Chemical Phenomena
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Chemistry, Physical
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Circular Dichroism
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Electron Spin Resonance Spectroscopy
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Fungi / drug effects
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Furans / analysis
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Furans / isolation & purification
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Furans / pharmacology
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Gram-Positive Bacteria / drug effects
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Mass Spectrometry
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Naphthacenes / analysis
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Naphthacenes / isolation & purification
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Naphthacenes / pharmacology
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Spectrophotometry, Ultraviolet
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Furans
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Naphthacenes
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cafamycin