A proposal for standardized grading of chronic changes in native kidney biopsy specimens

Kidney Int. 2017 Apr;91(4):787-789. doi: 10.1016/j.kint.2017.01.002.


Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade.

Keywords: arteriosclerosis; glomerulosclerosis; interstitial fibrosis; native kidney biopsy; tubular atrophy.

MeSH terms

  • Biopsy / standards*
  • Disease Progression
  • Humans
  • Kidney / pathology*
  • Predictive Value of Tests
  • Prognosis
  • Renal Insufficiency, Chronic / diagnosis*
  • Renal Insufficiency, Chronic / pathology
  • Renal Insufficiency, Chronic / therapy
  • Severity of Illness Index
  • Terminology as Topic*