INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters

Diabetologia. 2017 Jun;60(6):1152-1156. doi: 10.1007/s00125-017-4250-2. Epub 2017 Mar 18.

Elisabeth Kemter^{1

2}, Christian M Cohrs^{3

4

5}, Matthias Schäfer⁶, Marion Schuster⁷, Klaus Steinmeyer⁶, Lelia Wolf-van Buerck⁷, Andrea Wolf⁶, Annegret Wuensch^{8

9}, Mayuko Kurome^{8

9}, Barbara Kessler^{8

9}, Valeri Zakhartchenko^{8

9}, Matthias Loehn⁶, Yuri Ivashchenko⁶, Jochen Seissler⁷, Anke M Schulte⁶, Stephan Speier^{3

4

5}, Eckhard Wolf^{8

9

5}

¹ Chair for Molecular Animal Breeding and Biotechnology, Gene Centre, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany. kemter@genzentrum.lmu.de.
² Centre for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany. kemter@genzentrum.lmu.de.
³ Paul Langerhans Institute Dresden (PLID) of Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus of Technische Universität Dresden, Helmholtz Zentrum München, Neuherberg, Germany.
⁴ DFG-Centre for Regenerative Therapies Dresden (CRTD), Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
⁵ German Center for Diabetes Research (DZD), Munich, Neuherberg, Germany.
⁶ Diabetes Division, Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany.
⁷ Diabetes Center-Medical Clinic Campus Innenstadt, Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität, LMU Munich, Munich, Germany.
⁸ Chair for Molecular Animal Breeding and Biotechnology, Gene Centre, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany.
⁹ Centre for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany.

No abstract available

Keywords: Islet maturation; Pig; Reporter gene; Xenotransplantation.

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