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. 2017 Mar 6;6(2):72-78.
doi: 10.5527/wjn.v6.i2.72.

Monoclonal Gammopathy of Renal Significance: Diagnostic Workup

Free PMC article

Monoclonal Gammopathy of Renal Significance: Diagnostic Workup

Sofia O Correia et al. World J Nephrol. .
Free PMC article


The clinical spectrum of diseases associated with monoclonal gammopathies is wide and they are most commonly the consequence of renal deposition of monoclonal immunoglobulin or its components. The differential diagnosis is difficult and renal biopsy is essential. To distinguish many of these pathologies is necessary to use techniques that are not always available, even in tertiary central hospitals. This review will discuss the clinical presentation, pathologic features, treatment, prognosis and common diagnostic difficulties of these entities.

Keywords: Algorithm; Immunoglobulin; M protein; Monoclonal gammopathy of renal significance; Monoclonal gammopathy of undetermined significance.

Conflict of interest statement

Conflict-of-interest statement: None of the authors has any potential conflicts of interest related to this study.


Figure 1
Figure 1
Diagnostic work up. 1New sensitive method for early detection of amyloidosis in humans[36]. AH: Immunoglobulin heavy chain; AHL: Immunoglobulin heavy and light chain; AL: Immunoglobulin light chain; C3GN: C3 glomerulonephritis; DDD: Dense deposits disease; EM: Electronic microscopy; EP: Electrophoresis; FGN: Fibrillary glomerulonephritis; FLC: Free light chain assay; GN: Glomerulonephritis; GP: Glomerulopathy; IF: Immunofluorescence; Ig: Immunoglobulin; ITG: Immunotactoid glomerulonephritis; LC: Light chain; LM: Light microscopy; MG: Monoclonal gammopathy; MIDD: Monoclonal immunoglobulin deposition disease; MPGN: Membranoproliferative glomerulonephritis; PGNMID: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits.

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    1. Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA. Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood. 2012;120:4292–4295. - PubMed
    1. Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, et al. Diagnosis of monoclonal gammopathy of renal significance. Kidney Int. 2015;87:698–711. - PubMed
    1. van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, et al. The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network. Haematologica. 2014;99:984–996. - PMC - PubMed
    1. Lin J, Markowitz GS, Valeri AM, Kambham N, Sherman WH, Appel GB, D’Agati VD. Renal monoclonal immunoglobulin deposition disease: the disease spectrum. J Am Soc Nephrol. 2001;12:1482–1492. - PubMed
    1. Zand L, Kattah A, Fervenza FC, Smith RJ, Nasr SH, Zhang Y, Vrana JA, Leung N, Cornell LD, Sethi S. C3 glomerulonephritis associated with monoclonal gammopathy: a case series. Am J Kidney Dis. 2013;62:506–514. - PMC - PubMed