Expanding the tetrahydroquinoline pharmacophore

Bioorg Med Chem Lett. 2017 Apr 15;27(8):1714-1720. doi: 10.1016/j.bmcl.2017.02.077. Epub 2017 Mar 6.

Abstract

Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquinoline as neurotropic agents not reported earlier.

Keywords: Neurotropic agents; Povarov reaction; Tetrahydroquinoline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antitubercular Agents / chemical synthesis
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology
  • Cattle
  • Cell Line, Tumor
  • Cycloaddition Reaction
  • Drug Discovery
  • Humans
  • Mycobacterium bovis / drug effects
  • Neurogenesis / drug effects
  • Quinolines / chemical synthesis
  • Quinolines / chemistry*
  • Quinolines / pharmacology*
  • Small Molecule Libraries / chemical synthesis
  • Small Molecule Libraries / chemistry*
  • Small Molecule Libraries / pharmacology*
  • Tuberculosis, Bovine / drug therapy
  • Tuberculosis, Bovine / microbiology

Substances

  • Antineoplastic Agents
  • Antitubercular Agents
  • Quinolines
  • Small Molecule Libraries
  • 1,2,3,4-tetrahydroquinoline