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Multicenter Study
. 2017 Aug;52(8):1107-1112.
doi: 10.1038/bmt.2017.19. Epub 2017 Mar 20.

Long-term Follow-Up of a Retrospective Comparison of Reduced-Intensity Conditioning and Conventional High-Dose Conditioning for Allogeneic Transplantation From Matched Related Donors in Myelodysplastic Syndromes

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Multicenter Study

Long-term Follow-Up of a Retrospective Comparison of Reduced-Intensity Conditioning and Conventional High-Dose Conditioning for Allogeneic Transplantation From Matched Related Donors in Myelodysplastic Syndromes

R Martino et al. Bone Marrow Transplant. .

Abstract

This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P<0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.

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References

    1. Bone Marrow Transplant. 2010 Mar;45(3):450-7 - PubMed
    1. Semin Oncol. 2011 Oct;38(5):693-704 - PubMed
    1. Blood. 2014 Apr 10;123(15):2333-42 - PubMed
    1. Biol Blood Marrow Transplant. 2009 Feb;15(2):205-13 - PubMed
    1. J Clin Oncol. 2011 Jun 1;29(16):2230-9 - PubMed

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