FDOPA Patterns in Adrenal Glands: A Pictorial Essay

Clin Nucl Med. 2017 May;42(5):379-382. doi: 10.1097/RLU.0000000000001636.

Abstract

F-FDOPA is a well-established tool to explore pheochromocytomas. It tends to replace I-MIBG scan in metastatic pheochromocytomas, multiple endocrine neoplasia type 2-related tumors, succinate dehydrogenase [ubiquinone] iron-sulfur subunit-negative tumors, and succinate dehydrogenase[ZERO WIDTH SPACE]-positive lesions. To our knowledge, no study has characterized physiological and pathological adrenal glands with F-FDOPA from a quantitative point of view. We report the features of different normal and pathological adrenal glands with F-FDOPA. Within our series, only pheochromocytomas present a significantly increased uptake reflecting the high specificity of this tracer. Tumors such as adenomas or myelolipomas present no F-FDOPA significant accumulation. Interestingly, adrenal gland hyperplasia and solitary glands do not demonstrate compensatory uptake.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Adrenal Glands / diagnostic imaging*
  • Aged
  • Dihydroxyphenylalanine*
  • Female
  • Fluorine Radioisotopes*
  • Humans
  • Male
  • Middle Aged
  • Pheochromocytoma / diagnostic imaging*
  • Positron Emission Tomography Computed Tomography
  • Radiopharmaceuticals*

Substances

  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Dihydroxyphenylalanine