Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr;45:97-102.
doi: 10.1016/j.coi.2017.03.006. Epub 2017 Mar 17.

Plasma Cell and Memory B Cell Differentiation From the Germinal Center

Affiliations
Review

Plasma Cell and Memory B Cell Differentiation From the Germinal Center

Dan Suan et al. Curr Opin Immunol. .

Abstract

Germinal centers (GCs) form in secondary lymphoid tissues in response to antigenic challenge and are the site of somatic hypermutation, generating GC B cells with increasing affinity for the inciting agent that are positively selected over time. However, it is not until GC B cells differentiate into memory B cells and plasma cells and egress from the GC back into the circulation that effective long-lived humoral immunity is conferred upon the host. Here we review what is known about the signals that initiate the transition from a GC B cell into the memory B cell and plasma cell compartments and the downstream transcriptional regulation of these processes.

Similar articles

See all similar articles

Cited by 27 articles

See all "Cited by" articles

LinkOut - more resources

Feedback