Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats

J Nutr Biochem. 2017 May;43:151-155. doi: 10.1016/j.jnutbio.2017.02.009. Epub 2017 Mar 8.

Abstract

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a dimethylated analog of resveratrol and has been reported to exert various pharmacological effects. In this study, we evaluated the effect of pterostilbene on the pathogenesis of obesity and energy metabolism in obese rats. Pterostilbene significantly activates silent mating type information regulation 2 homolog-1 and peroxisome proliferator-activated receptor-alpha in vitro. At 4 weeks a 0.5% pterostilbene diet markedly suppressed the abdominal white adipose tissue (WAT) accumulation in obese rats. The oxygen consumption and energy expenditure were significantly higher in the pterostilbene group, and pterostilbene increased the fat metabolism rather than the carbohydrate metabolism in obese rats. The mRNA level of uncoupling protein, a thermogenic regulator, was increased and the mRNA levels of fatty acid synthase and leptin, which are involved in lipogenesis and fat storage, were markedly decreased in WAT after the pterostilbene feeding. These results suggest that pterostilbene prevents WAT accumulation through the enhancement of energy metabolism and partly the suppression of lipogenesis in obese OLETF rats.

Keywords: Energy expenditure; Obesity; PPARα; Pterostilbene; SIRT1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Animals
  • Dietary Supplements
  • Disease Models, Animal
  • Energy Metabolism / drug effects*
  • Gene Expression Regulation / drug effects
  • Lipid Metabolism / drug effects
  • Male
  • Obesity / diet therapy
  • Obesity / metabolism*
  • PPAR alpha / metabolism
  • Rats
  • Sirtuin 1 / metabolism
  • Stilbenes / pharmacology*

Substances

  • PPAR alpha
  • Stilbenes
  • pterostilbene
  • Sirt1 protein, rat
  • Sirtuin 1