Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2017 Jun 1;174(6):566-575.
doi: 10.1176/appi.ajp.2017.16080897. Epub 2017 Mar 21.

Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents

Affiliations
Free PMC article
Multicenter Study

Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents

Josiane Bourque et al. Am J Psychiatry. .
Free PMC article

Abstract

Objective: This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing. A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later.

Method: Functional imaging responses to three paradigms-the stop-signal, monetary incentive delay, and faces tasks-were collected in youths at age 14, as part of the IMAGEN study. At baseline, youths from London and Dublin sites were assessed on psychotic-like experiences, and those reporting significant experiences were compared with matched control subjects. Significant brain activity differences between the groups were used to predict, with cross-validation, the presence of psychotic symptoms in the context of mood fluctuation at age 16, assessed in the full sample. These prediction analyses were conducted with the London-Dublin subsample (N=246) and the full sample (N=1,196).

Results: Relative to control subjects, youths reporting psychotic-like experiences showed increased hippocampus/amygdala activity during processing of neutral faces and reduced dorsolateral prefrontal activity during failed inhibition. The most prominent regional difference for classifying 16-year-olds with mood fluctuation and psychotic symptoms relative to the control groups (those with mood fluctuations but no psychotic symptoms and those with no mood symptoms) was hyperactivation of the hippocampus/amygdala, when controlling for baseline psychotic-like experiences and cannabis use.

Conclusions: The results stress the importance of the limbic network's increased response to neutral facial stimuli as a marker of the extended psychosis phenotype. These findings might help to guide early intervention strategies for at-risk youths.

Keywords: Adolescents; Brain Imaging Techniques; Mood Disorders-Bipolar; Psychosis.

Conflict of interest statement

Disclosures: The other authors report no biomedical financial interests or potential conflicts of interest.

Figures

Figure 1
Figure 1
Cluster-corrected activation differences between 14-year olds with (N=27) and without (N=135) psychotic-like experiences. Abbreviations: PLEs, Psychotic-like experiences. Only cluster-corrected activations are shown in the maps. Bar graphs refer to standard deviations (SD).
Figure 2
Figure 2
Receiver-operating characteristics (ROC) curves A, ROC of age 16 classification between youth from the London-Dublin subsample with mood and psychosis symptoms and those with no mood symptoms B, ROC of age 16 classification between youth from the full sample with mood and psychosis symptoms and those with no mood symptoms C, ROC of age 16 classification between youth from the full sample with mood and psychosis symptoms and those with mood symptoms only D, ROC of age 16 classification between youth from the full sample with mood symptoms only and those with no mood symptoms

Similar articles

See all similar articles

Cited by 4 articles

Publication types

MeSH terms

LinkOut - more resources

Feedback