Intestinal-Type Adenocarcinoma: Classification, Immunophenotype, Molecular Features and Differential Diagnosis

Head Neck Pathol. 2017 Sep;11(3):295-300. doi: 10.1007/s12105-017-0800-7. Epub 2017 Mar 20.


Intestinal-type adenocarcinoma is the second most frequent sinonasal adenocarcinoma. High incidence of these tumors is seen among workers with occupational wood dust exposure, particularly of hardwood dusts. Intestinal-type adenocarcinoma has striking histomorphologic and immunophenotypic similarities with colorectal adenocarcinomas, but on the level of molecular pathologic mechanisms these tumors have their own specific features different from gastrointestinal tumors. This article provides an update on current histopathologic classification of intestinal-type adenocarcinomas, their immunophenotypic properties, recent advances in molecular pathologic features and differential diagnostic considerations.

Keywords: Head and neck adenocarcinoma; Immunohistochemistry; Intestinal-type adenocarcinoma; Molecular pathology; Sinonasal adenocarcinoma; Sinonasal nonintestinal adenocarcinoma; Wood dust exposure.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma*
  • Diagnosis, Differential
  • Humans
  • Immunophenotyping
  • Paranasal Sinus Neoplasms*