Pluripotent stem cells in neuropsychiatric disorders

Mol Psychiatry. 2017 Sep;22(9):1241-1249. doi: 10.1038/mp.2017.40. Epub 2017 Mar 21.


Neuropsychiatric disorders place an enormous medical burden on patients across all social and economic ranks. The current understanding of the molecular and cellular causes of neuropsychiatric disease remains limited, which leads to a lack of targeted therapies. Human-induced pluripotent stem cell (iPSC) technology offers a novel platform for modeling the genetic contribution to mental disorders and yields access to patient-specific cells for drug discovery and personalized medicine. Here, we review recent progress in using iPSC technology to model and potentially treat neuropsychiatric disorders by focusing on the most prevalent conditions in psychiatry, including depression, anxiety disorders, bipolar disorder and schizophrenia.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bipolar Disorder / metabolism
  • Humans
  • Induced Pluripotent Stem Cells
  • Mental Disorders / physiopathology*
  • Mental Disorders / therapy*
  • Pluripotent Stem Cells / metabolism*
  • Pluripotent Stem Cells / physiology
  • Precision Medicine / psychology
  • Schizophrenia / genetics