The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

Chem Commun (Camb). 2017 Apr 20;53(33):4565-4568. doi: 10.1039/c6cc09900a.

Abstract

We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

MeSH terms

  • Drug Carriers / chemistry
  • Drug Carriers / metabolism
  • Endosomes / chemistry
  • Endosomes / metabolism
  • Fluorescence
  • HeLa Cells
  • Hemagglutinins, Viral / chemistry*
  • Hemagglutinins, Viral / genetics
  • Hemagglutinins, Viral / metabolism
  • Humans
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Receptors, CXCR4 / chemistry*
  • Receptors, CXCR4 / metabolism
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / metabolism
  • Tumor Cells, Cultured

Substances

  • CXCR4 protein, human
  • Drug Carriers
  • Hemagglutinins, Viral
  • Receptors, CXCR4
  • Receptors, Cell Surface
  • hemagglutinin HA-2 fusogenic peptide, Influenza virus