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. 2017 May 15;246:46-50.
doi: 10.1016/j.ygcen.2017.03.011. Epub 2017 Mar 18.

Thymus: Conservation in Evolution


Thymus: Conservation in Evolution

Antonella Franchini et al. Gen Comp Endocrinol. .


From an evolutionary point of view, the thymus is a new organ observed for the first time in fish concomitantly with the appearance of adaptive clonotypical immunity. Hormone and neuropeptide expression was demonstrated in different species suggesting a conserved role of these molecules. An integrated evolution of immune and neuroendocrine responses appears to have been realized by means of the re-use of ancestral material, such as neuroendocrine cells and mediators, to create a thymic microenvironment for the maturation and differentiation of T cells.

Keywords: Apoptosis; Evolution; POMC-derived peptides; Thymus.

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