Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2)

Immunol Lett. 1988 Jan;17(1):41-5. doi: 10.1016/0165-2478(88)90099-5.

Abstract

Recombinant B cell stimulatory factor 2 (rBSF-2) did not display any detectable level of antiviral activity when using human diploid fibroblasts, DIP-2, FS-4, FS-7, amnion-derived WISH and FL cells with vesicular stomatitis virus (VSV) and Sindbis virus as challenging agents (less than 2.5 X 10(2) IU/mg). Furthermore anti-IFN-beta could not neutralize the immunoglobulin-inducing activity of BSF-2. Moreover anti-BSF-2 could not neutralize the antiviral activity of IFN-beta. The data indicate that BSF-2 is functionally and immunologically not related to IFNs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cross Reactions
  • Interferon Type I / immunology
  • Interleukin-6
  • Interleukins / immunology
  • Interleukins / pharmacology*
  • Recombinant Proteins / pharmacology
  • Sindbis Virus / drug effects
  • Vesicular stomatitis Indiana virus / drug effects
  • Viruses / drug effects*

Substances

  • Interferon Type I
  • Interleukin-6
  • Interleukins
  • Recombinant Proteins