Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study)

J Orthop Trauma. 2017 Apr;31 Suppl 1:S71-S77. doi: 10.1097/BOT.0000000000000793.

Abstract

Poor pain control after orthopaedic trauma is a predictor of physical disability and numerous negative long-term outcomes. Despite increased awareness of the negative consequences of poorly controlled pain, analgesic therapy among hospitalized patients after orthopaedic trauma remains inconsistent and often inadequate. The Pain study is a 3 armed, prospective, double-blind, multicenter randomized trial designed to evaluate the effect of standard pain management versus standard pain management plus perioperative nonsteroidal anti-inflammatory drugs or pregabalin in patients of ages 18-85 with extremity fractures. The primary outcomes are chronic pain, opioid utilization during the 48 hours after definitive fixation and surgery for nonunion in the year after fixation. Secondary outcomes include preoperative and postoperative pain intensity, adverse events and complications, physical function, depression, and post-traumatic stress disorder. One year treatment costs are also compared between the groups.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid / administration & dosage*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Chronic Pain / diagnosis
  • Chronic Pain / etiology
  • Chronic Pain / prevention & control*
  • Double-Blind Method
  • Drug Therapy, Combination / methods
  • Female
  • Fracture Fixation / adverse effects*
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Pain Management / methods*
  • Pain Measurement / drug effects
  • Pain, Postoperative / diagnosis
  • Pain, Postoperative / etiology
  • Pain, Postoperative / prevention & control*
  • Prospective Studies
  • Quality Improvement
  • Treatment Outcome
  • United States
  • Young Adult

Substances

  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal