Recent updates of carbapenem antibiotics

Eur J Med Chem. 2017 May 5:131:185-195. doi: 10.1016/j.ejmech.2017.03.022. Epub 2017 Mar 16.


Carbapenems are among the most commonly used and the most efficient antibiotics since they are relatively resistant to hydrolysis by most β-lactamases, they target penicillin-binding proteins, and generally have broad-spectrum antibacterial effect. In this review, we described the initial discovery and development of carbapenems, chemical characteristics, in vitro/in vivo activities, resistance studies, and clinical investigations for traditional carbapenem antibiotics in the market; imipenem-cilastatin, meropenem, ertapenem, doripenem, biapenem, panipenem/betamipron in addition to newer carbapenems such as razupenem, tebipenem, tomopenem, and sanfetrinem. We focused on the literature published from 2010 to 2016.

Keywords: Antibiotic resistance; Carbapenems; β-lactamases; β-lactams.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / drug effects*
  • Carbapenems / chemistry
  • Carbapenems / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure


  • Carbapenems