Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar 17;6:315-326.
doi: 10.1016/j.omtn.2017.01.005. Epub 2017 Feb 9.

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine

Affiliations
Free PMC article
Review

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine

Célia Dupain et al. Mol Ther Nucleic Acids. .
Free PMC article

Abstract

Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion genes in the development of pediatric cancers. Fusion genes result from chromosomal rearrangements leading to the juxtaposition of two genes. Consequently, an abnormal activation of one or both genes is observed. The detection of fusion genes has generated great interest in basic cancer research and in the clinical setting, since these genes can lead to better comprehension of the biological mechanisms of tumorigenesis and they can also be used as therapeutic targets and diagnostic or prognostic biomarkers. In this review, we discuss the molecular mechanisms of fusion genes and their particularities in pediatric cancers, as well as their relevance in murine models and in the clinical setting. We also point out the difficulties encountered in the discovery of fusion genes. Finally, we discuss future perspectives and priorities for finding new innovative therapies in childhood cancer.

Keywords: chromosomic rearrangements; fusion genes; pediatric cancers; precision medicine.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

References

    1. American Cancer Society (2016). Key statistics for childhood cancers. https://www.cancer.org/cancer/cancerinchildren/detailedguide/cancer-in-children-key-statistics.
    1. Bahadur G., Hindmarsh P. Age definitions, childhood and adolescent cancers in relation to reproductive issues. Hum. Reprod. 2000;15:227. - PubMed
    1. Minnesota Department of Health (2016). Childhood cancers: facts and figures. https://apps.health.state.mn.us/mndata/cancer_child#childbraincancer_year.
    1. Fidler M.M., Reulen R.C., Winter D.L., Kelly J., Jenkinson H.C., Skinner R., Frobisher C., Hawkins M.M., British Childhood Cancer Survivor Study Steering Group Long term cause specific mortality among 34 489 five year survivors of childhood cancer in Great Britain: population based cohort study. BMJ. 2016;354:i4351. - PMC - PubMed
    1. Marshall G.M., Carter D.R., Cheung B.B., Liu T., Mateos M.K., Meyerowitz J.G., Weiss W.A. The prenatal origins of cancer. Nat. Rev. Cancer. 2014;14:277–289. - PMC - PubMed

LinkOut - more resources

Feedback