Effects of essential oil exposure on salivary estrogen concentration in perimenopausal women

Neuro Endocrinol Lett. 2017 Jan;37(8):567-572.


Objectives: The menopausal transition is the time from the onset of menstrual changes until one year after the final menstrual period. During this phase, perimenopausal women experience a variety of health-related symptoms, which seemingly derive from declining level of estrogen secretion. It has long been recognized that some essential oils have the efficacy of alleviating menopausal symptoms. On the basis of this, it is possible that these essential oils have the potency to facilitate estrogen secretion in women. The present study investigated this possibility by examining if the olfactory exposure to the essential oil increase salivary estrogen concentration.

Methods: We tested the effect of ten essential oils; clary sage, frankincense, geranium, lavender, jasmine absolute, neroli, rose otto, ylang ylang, orange and roman chamomile, which are thought to relieve perimenopasal symptoms.

Results: The results have shown increase of salivary estrogen concentration induced by exposure to geranium and rose otto compared to control odor.

Conclusion: Together with the previous studies, the present study may give support to the notion that olfactory exposure to some essential oils can influence salivary concentration of estrogen.

MeSH terms

  • Adult
  • Estradiol / blood
  • Estrogens / metabolism*
  • Female
  • Humans
  • Middle Aged
  • Oils, Volatile / administration & dosage
  • Oils, Volatile / pharmacology*
  • Perimenopause / metabolism*
  • Salivary Glands / metabolism*
  • Smell / physiology


  • Estrogens
  • Oils, Volatile
  • Estradiol