Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL

Mar Drugs. 2017 Mar 22;15(3):86. doi: 10.3390/md15030086.

Abstract

Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spectrometry (LC-MS/MS) to analyze the mass spectrometric characteristics of the isolated compounds as well as the crude extracts. As a result, three other analogs were detected, and their structures were deduced according to the similar fragmentation patterns. This is the first systematic report on the mass spectrometric characteristics of prenylated indole derivatives.

Keywords: LC-MS/MS analysis; Penicillium sp. NH-SL; cytotoxic activity; mass spectrometric characteristics; prenylated indole alkaloids.

MeSH terms

  • Animals
  • Aquatic Organisms / chemistry*
  • Cell Line
  • Indole Alkaloids / chemistry*
  • Mice
  • Penicillium / chemistry*
  • Prenylation / drug effects*
  • Tandem Mass Spectrometry / methods

Substances

  • Indole Alkaloids