Macrophages: micromanagers of antagonistic signaling nanoclusters

J Cell Biol. 2017 Apr 3;216(4):871-873. doi: 10.1083/jcb.201702028. Epub 2017 Mar 22.


How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Ligands
  • Macrophages / physiology*
  • Receptors, Cell Surface / metabolism
  • Signal Transduction / physiology*


  • Ligands
  • Receptors, Cell Surface