Artificial and natural RNA interactions between bacteria and C. elegans

RNA Biol. 2017 Apr 3;14(4):415-420. doi: 10.1080/15476286.2017.1297912. Epub 2017 Mar 23.


Nineteen years after Lisa Timmons and Andy Fire first described RNA transfer from bacteria to C. elegans in an experimental setting 48 the biologic role of this trans-kingdom RNA-based communication remains unknown. Here we summarize our current understanding on the mechanism and potential role of such social RNA.

Keywords: Bacteria; C. elegans; environmental RNAi; mobile RNA.

Publication types

  • Review

MeSH terms

  • Animal Feed
  • Animals
  • Bacteria / genetics*
  • Caenorhabditis elegans / genetics*
  • Gene Expression Regulation
  • RNA Interference*
  • RNA, Bacterial / genetics
  • RNA, Helminth / genetics


  • RNA, Bacterial
  • RNA, Helminth