A Newborn with Transient Diabetes Mellitus Accompanied by Ketoacidosis Attributable to a ZFP57 Mutation

J Trop Pediatr. 2017 Oct 1;63(5):399-401. doi: 10.1093/tropej/fmx005.


Hyperglycemia commencing within the first 6 months of life requires exogenous insulin therapy and, if the condition persists for >2 weeks, is termed neonatal diabetes mellitus (NDM). This rare illness is of two types: transient and permanent NDM. Most cases come to medical attention because of nonspecific symptoms, including intrauterine growth retardation, dehydration, difficulties in feeding and inadequate weight gain. In the present article, we describe an infant who smelt of ketones during examination and who was diagnosed with transient NDM caused by a ZFP57 mutation, accompanied by ketoacidosis. This is the first report of such a condition.

Keywords: ZFP57 gene mutation; ketoacidosis; transient neonatal diabetes mellitus.

Publication types

  • Case Reports

MeSH terms

  • DNA-Binding Proteins
  • Dehydration / etiology
  • Diabetes Mellitus / diagnosis*
  • Diabetes Mellitus / genetics
  • Diabetic Ketoacidosis / congenital
  • Diabetic Ketoacidosis / diagnosis*
  • Diabetic Ketoacidosis / drug therapy
  • Female
  • Humans
  • Hyperglycemia / drug therapy
  • Hypoglycemic Agents / therapeutic use
  • Infant, Newborn
  • Infant, Newborn, Diseases / diagnosis*
  • Infant, Newborn, Diseases / genetics
  • Insulin / administration & dosage
  • Insulin / therapeutic use
  • Male
  • Mutation
  • Repressor Proteins
  • Transcription Factors


  • DNA-Binding Proteins
  • Hypoglycemic Agents
  • Insulin
  • Repressor Proteins
  • Transcription Factors
  • ZFP57 protein, human

Supplementary concepts

  • Diabetes Mellitus, Transient Neonatal, 1