Operationalizing Compensation Over Time in Neurodegenerative Disease

Brain. 2017 Apr 1;140(4):1158-1165. doi: 10.1093/brain/awx022.


In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al. present two mathematical models of compensation over time and their operationalisation for neuroimaging.

Keywords: Huntington’s disease; MRI; compensation; longitudinal analysis; neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Huntington Disease / physiopathology*
  • Models, Theoretical
  • Neurodegenerative Diseases / physiopathology*