Comparison of Cobas® HPV and Anyplex™ II HPV28 assays for detecting and genotyping human papillomavirus

Diagn Microbiol Infect Dis. 2017 Jan;87(1):25-27. doi: 10.1016/j.diagmicrobio.2016.08.022. Epub 2016 Aug 28.

Abstract

Persistent infection with high-risk human papillomavirus (HPV-HR) is a recognized cause of cervical cancer. The aim of this study was to compare analytical and clinical performances of the Cobas® HPV and Anyplex™ II HPV28 assays for HPV detection and genotyping. A total of 94 cervical samples were tested. For HPV-HR, the results agreed very well (94.68%), with 100% agreement when detecting CIN2+. The Anyplex™ II HPV28 assay detected more genotypes than the Cobas® HPV Test, but their clinical performances were similar.

Keywords: Anyplex™ II HPV28; HPV genotyping; Human papillomavirus; Real-time PCR.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Genotyping Techniques / methods*
  • Humans
  • Middle Aged
  • Molecular Diagnostic Techniques / methods*
  • Papillomaviridae / classification*
  • Papillomaviridae / genetics
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / virology*
  • Young Adult