Emergence of norovirus GII.2 and its novel recombination during the gastroenteritis outbreak in Japanese children in mid-2016

Infect Genet Evol. 2017 Jul;51:86-88. doi: 10.1016/j.meegid.2017.03.020. Epub 2017 Mar 20.

Abstract

In mid-2016, norovirus GII.2 emerged as a major cause of gastroenteritis outbreak in Japan with overall detection rate of 56.3% of norovirus cases. The differences in ORF1 and ORF2 of some norovirus GII were observed. Inter-subtype recombinants GII.Pe/GII.2, GII.P16/GII.2 and GII.P17/GII.2 were detected. Three amino acid substitutions were noted at P2 antigenic site of GII.P16/GII.2 recombinants. Furthermore, this study revealed that the current immunochromatographic kit available in Japan could be used effectively for the detection of recent GII.2 genotype.

Keywords: Gastroenteritis; Japan; Norovirus; Outbreak; Recombinant.

MeSH terms

  • Amino Acid Substitution
  • Caliciviridae Infections / epidemiology*
  • Caliciviridae Infections / transmission
  • Caliciviridae Infections / virology
  • Child
  • Chromatography, Affinity
  • Disease Outbreaks*
  • Feces / virology
  • Gastroenteritis / epidemiology*
  • Gastroenteritis / virology
  • Gene Expression
  • Genotype*
  • Humans
  • Japan / epidemiology
  • Norovirus / classification
  • Norovirus / genetics*
  • Norovirus / immunology
  • Norovirus / isolation & purification
  • Phylogeny
  • Recombination, Genetic
  • Viral Proteins / genetics*
  • Viral Proteins / immunology

Substances

  • Viral Proteins